Endocrine Abstracts

Obesity, characterized by excess intra-abdominal adipose tissue, is closely associated with a cluster of metabolic disorders such as type 2 diabetes mellitus (T2DM). Our previous study revealed significant associations between interleukin 4 (IL4) genotypes and T2DM, as well as IL4 genotypes and high density lipoprotein-cholesterol levels. Our most recent study results reveal that IL4 has anti-hyperglycemic function by improving insulin sensitivity and glucose tolerance. In add...

Background and aims: Incretin mimetics are a new class of pharmacological agents with antihyperglycemic actions that mimic the actions of incretin hormones originating in the gut, such as glucagon-like peptide (GLP)-1. The thyroid gland exhibit a strong GLP-1 receptor expression in rodents but only low receptor levels in humans. GLP-1 receptors activation stimulates calcitonin secretion and promotes the development of C cell hyperplasia and medullary thyroid cancer in rodents....

Objectives-Aim: Oxidized low-density lipoprotein (LDL) seems to play an important role in the etiology of atherosclerosis. They stumulate atherosclerosis. Glucocorticoids decrease LDL degradation and expression of LDL receptor. Morever insulin resistance in glucocorticoid excess state may contribute to LDL oxidation changes. The aim of this study was to investigate, the LDL oxidation in glucocorticoid excess state and the effect of atorvastatin on LDL oxidation.<p class="...

Aim: The aim of this study was to investigate the role of C-reactive protein (CRP) in gestational diabetes mellitus.Material and methods: We studied 65 healthy pregnant women aged 29.75±5.59 years. All women referred for a 100–g oral glucose tolerance test following an abnormal result on a screening. The demographic data, waist circumference, height, and weight of the participants were recorded. Fasting levels of insulin, triglycerides (TG), CR...

There are difficulties in establishing the diagnosis of gonadotropinomas using serum hormonal levels, even after intravenous TRH. We evaluated the relationship between humoral (serum and cerebrospinal fluid - CSF) levels of gonadotropins and the immunohistochemical evidence in tumor tissue.Serum and CSF levels of pituitary hormones were assayed using rapid fluoroimmunometry with Europium. Immunohistochemistry (IHC) was performed with avidin-biotine. Grou...

Aim: Analyzing the evolution of thyroid function in thyroiditis and related disease during 1–15 years.Materials and methods: A) Diagnostic: Hashimoto thyroiditis (HT): i) antithyroperoxydase antibodies (ATPO) cut-off 34. ii) If ATPO=normal (N), was considered thyroiditis with only antithyroglobuline antibodies (T-ATG); iii) idiopathic mixedema (IM): hypothyroidism, no ATPO, no ATG, no TRAB.B) Patients: i) HT: 1092; T-ATG: 61; ...

In Ukraine, in 2017, an estimated 53000 people were living with chronic hepatitis C virus (HCV) infection, and its prevalence rate was 123.7 patients per 100000 citizens. Symptoms of at least one extra hepatic manifestations appear in more than 50% of HCV-positive patients, and thyroid abnormalities are rather common. The purpose of the study was to determine the prevalence of thyroid function tests and anti-thyroid autoantibodies abnormalities in the untreated patients with c...

Ectopic thyroid tissue, defined as thyroid tissue not located anterolaterally to the second and fourth tracheal cartages, is rare. In the majority of the cases it is located in the midline, between the foramen caecum and the proper location of the thyroid gland and most often it is found in the base of the tongue. We present a case of ectopic thyroid in the lower cervical area in a patient with a multinodular goiter. A 27-yr-old asymptomatic woman presented with a recent histo...

Central obesity is strongly associated with insulin resistance and chronic sub-clinical inflammation, which is implicated in the development of type 2 diabetes (T2DM). However, the mechanisms underlying this link remain unclear. Recently JNK, a mitogen activated protein kinase (MAPK), has been implicated in obesity and insulin resistance by interfering with insulin action. Studies in rodent models show that phosphorylated JNK-1 is elevated in obesity, whilst the absence of JNK...

Background: Substantial deposition of iron in the thyroid gland is a frequent autopsy finding in patients with genetic haemochromatosis. Despite this there have been relatively few reports, mainly isolated cases, of significant thyroid dysfunction in such patients. In one large study Edwards et al. (1983) observed primary hypothyroidism in 6.1% of cases, all subjects were male and had elevated titres of antithyroid antibodies.Aim: The aim of this prosp...